Influenza B virus-specific CD8( ) T-lymphocytes strongly cross-react with viruses of the opposing influenza B lineage
Carolien E van de Sandt, YingYing Dou, Stella E Vogelzang-van Trierum, Kim B Westgeest, Mark R Pronk, Albert DME Osterhaus, Ron AM Fouchier, Guus F Rimmelzwaan, Marine LB Hillaire
Journal of General Virology | MICROBIOLOGY SOC | Published : 2015
Influenza B viruses fall in two antigenically distinct lineages (B/Victoria/2/1987 and B/Yamagata/16/1988 lineage) that co-circulate with influenza A viruses of the H3N2 and H1N1 subtypes during seasonal epidemics. Infections with influenza B viruses contribute considerably to morbidity and mortality in the human population. Influenza B virus neutralizing antibodies, elicited by natural infections or vaccination, poorly cross-react with viruses of the opposing influenza B lineage. Therefore, there is an increased interest in identifying other correlates of protection which could aid the development of broadly protective vaccines. blast analysis revealed high sequence identity of all viral pr..View full abstract
Awarded by NIAID/NIH
Awarded by EU
Awarded by European Commission ERC
R. A. M. F. received funding from the NIAID/NIH (HHSN272201400008C). G. F. R. received funding from EU grant FLUNIVAC (project ID 602604). A. D. M. E. O. was supported by the European Commission ERC project FLUPLAN (project ID 101920).