Journal article

Influenza B virus-specific CD8( ) T-lymphocytes strongly cross-react with viruses of the opposing influenza B lineage

Carolien E van de Sandt, YingYing Dou, Stella E Vogelzang-van Trierum, Kim B Westgeest, Mark R Pronk, Albert DME Osterhaus, Ron AM Fouchier, Guus F Rimmelzwaan, Marine LB Hillaire

Journal of General Virology | MICROBIOLOGY SOC | Published : 2015

Abstract

Influenza B viruses fall in two antigenically distinct lineages (B/Victoria/2/1987 and B/Yamagata/16/1988 lineage) that co-circulate with influenza A viruses of the H3N2 and H1N1 subtypes during seasonal epidemics. Infections with influenza B viruses contribute considerably to morbidity and mortality in the human population. Influenza B virus neutralizing antibodies, elicited by natural infections or vaccination, poorly cross-react with viruses of the opposing influenza B lineage. Therefore, there is an increased interest in identifying other correlates of protection which could aid the development of broadly protective vaccines. blast analysis revealed high sequence identity of all viral pr..

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