Journal article

Increased Protein Degradation Improves Influenza Virus Nucleoprotein-Specific CD8( ) T Cell Activation In Vitro but Not in C57BL/6 Mice

Arwen F Altenburg, Carolien E van de Sandt, Stella E van Trierum, Heidi LM De Gruyter, Peter RWA van Run, Ron AM Fouchier, Kenny Roose, Xavier Saelens, Asisa Volz, Gerd Sutter, Rory D de Vries, Guus F Rimmelzwaan

Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2016

Abstract

Due to antigenic drift of influenza viruses, seasonal influenza vaccines need to be updated annually. These vaccines are based on predictions of strains likely to circulate in the next season. However, vaccine efficacy is greatly reduced in the case of a mismatch between circulating and vaccine strains. Furthermore, novel antigenically distinct influenza viruses are introduced into the human population from animal reservoirs occasionally and may cause pandemic outbreaks. To dampen the impact of seasonal and pandemic influenza, vaccines that induce broadly protective and long-lasting immunity are preferred. Because influenza virus-specific CD8+ T cells are directed mainly against relatively c..

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