Differential Recognition of Influenza A Viruses by M1(58-66) Epitope-Specific CD8( ) T Cells Is Determined by Extraepitopic Amino Acid Residues
Carolien E van de Sandt, Joost HCM Kreijtz, Martina M Geelhoed-Mieras, Nella J Nieuwkoop, Monique I Spronken, David AMC van de Vijver, Ron AM Fouchier, Albert DME Osterhaus, Guus F Rimmelzwaan
Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2016
UNLABELLED: Natural influenza A virus infections elicit both virus-specific antibody and CD4(+) and CD8(+) T cell responses. Influenza A virus-specific CD8(+) cytotoxic T lymphocytes (CTLs) contribute to clearance of influenza virus infections. Viral CTL epitopes can display variation, allowing influenza A viruses to evade recognition by epitope-specific CTLs. Due to functional constraints, some epitopes, like the immunodominant HLA-A*0201-restricted matrix protein 1 (M158-66) epitope, are highly conserved between influenza A viruses regardless of their subtype or host species of origin. We hypothesized that human influenza A viruses evade recognition of this epitope by impairing antigen pro..View full abstract
Awarded by EU FLUNIVAC
Awarded by HHS \ NIH \ National Institute of Allergy and Infectious Diseases (NIAID)
EU FLUNIVAC provided funding to Guus F. Rimmelzwaan under grant number 602604. HHS vertical bar NIH vertical bar National Institute of Allergy and Infectious Diseases (NIAID) provided funding to Monique I. J. Spronken and Ron A. M. Fouchier under grant number HHSN272201400008C.