Journal article

Human Influenza A Virus-Specific CD8( ) T-Cell Response Is Long-lived

Carolien E van de Sandt, Marine LB Hillaire, Martina M Geelhoed-Mieras, Albert DME Osterhaus, Ron AM Fouchier, Guus F Rimmelzwaan

The Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2015

Abstract

Animal and human studies have demonstrated the importance of influenza A virus (IAV)-specific CD8(+) cytotoxic T lymphocytes (CTLs) in heterosubtypic cross-protective immunity. Using peripheral blood mononuclear cells obtained intermittently from healthy HLA-typed blood donors between 1999 and 2012, we were able to demonstrate that IAV-specific CTLs are long-lived. Intercurrent IAV infections transiently increase the frequency of functionally distinct subsets of IAV-specific CTLs, in particular effector and effector memory T cells.

Grants

Awarded by National Institute of Allergy and Infectious Diseases, National Institutes of Health


Awarded by European Union


Awarded by European Commission


Funding Acknowledgements

This work was supported by National Institute of Allergy and Infectious Diseases, National Institutes of Health (contract HHSN272201400008C to R. A. M. F.); the European Union (project 602604 to G. F. R. on behalf of FLUNIVAC); and the European Commission (project 101920 to A. D. M. E. O. on behalf of ERC project FLUPLAN).