Journal article

Exploring the Impact of Quality of Life on Survival: A Case Study in Total Knee Replacement Surgery

Michelle Tew, Kim Dalziel, Michelle Dowsey, Peter F Choong, Philip Clarke

Medical Decision Making | SAGE PUBLICATIONS INC | Published : 2020


Background. There is growing evidence that quality of life (QoL) has a strong association with mortality. However, incorporation of QoL is uncommon in standard survival modeling. Methods. Using data extracted from a registry of patients undergoing total knee replacement (TKR), the impact of incorporating QoL in survival modeling was explored using 4 parametric survival models. QoL was incorporated and tested in 2 forms, which are baseline and change in QoL due to intervention. Life expectancy and quality-adjusted life years (QALYs) were calculated and comparisons made to a reference model (no QoL) to translate the findings in the context of modeled economic evaluations. Results. A total of 2..

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