Inter-organelle Communication in the Pathogenesis of Mitochondrial Dysfunction and Insulin Resistance
Stacey N Keenan, Matthew J Watt, Magdalene K Montgomery
CURRENT DIABETES REPORTS | CURRENT MEDICINE GROUP | Published : 2020
PURPOSE OF REVIEW: Impairments in mitochondrial function in patients with insulin resistance and type 2 diabetes have been disputed for decades. This review aims to briefly summarize the current knowledge on mitochondrial dysfunction in metabolic tissues and to particularly focus on addressing a new perspective of mitochondrial dysfunction, the altered capacity of mitochondria to communicate with other organelles within insulin-resistant tissues. RECENT FINDINGS: Organelle interactions are temporally and spatially formed connections essential for normal cell function. Recent studies have shown that mitochondria interact with various cellular organelles, such as the endoplasmic reticulum, lys..View full abstract
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Awarded by NHMRC
MJW and MKM are supported by Research Fellowships from the NHMRC (APP1077703, APP1143224).