Journal article

Inter-organelle Communication in the Pathogenesis of Mitochondrial Dysfunction and Insulin Resistance

Stacey N Keenan, Matthew J Watt, Magdalene K Montgomery

CURRENT DIABETES REPORTS | CURRENT MEDICINE GROUP | Published : 2020

Abstract

PURPOSE OF REVIEW: Impairments in mitochondrial function in patients with insulin resistance and type 2 diabetes have been disputed for decades. This review aims to briefly summarize the current knowledge on mitochondrial dysfunction in metabolic tissues and to particularly focus on addressing a new perspective of mitochondrial dysfunction, the altered capacity of mitochondria to communicate with other organelles within insulin-resistant tissues. RECENT FINDINGS: Organelle interactions are temporally and spatially formed connections essential for normal cell function. Recent studies have shown that mitochondria interact with various cellular organelles, such as the endoplasmic reticulum, lys..

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