Tuberculosis contact investigation and short-course preventive therapy among young children in Africa
V Schwoebel, KG Koura, M Adjobimey, S Gnanou, AG Wandji, J-C Gody, C Delacourt, A Detjen, SM Graham, E Masserey, P Mselatti, A Roggi, A Trebucq
International Journal of Tuberculosis and Lung Disease | INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) | Published : 2020
SETTING: The largest cities in Benin, Burkina Faso, Cameroon and Central African Republic.OBJECTIVE: To demonstrate the feasibility and document the effectiveness of household contact investigation and preventive therapy in resource-limited settings.DESIGN: Children under 5 years living at home with adults with bacteriologically confirmed pulmonary tuberculosis (TB) were screened using questionnaire, clinical examination, tuberculin skin test and chest X-ray. Children free of active TB were offered preventive treatment with a 3-month rifampicin-isoniazid (3RH) or 6-month isoniazid (6H) regimen in Benin. Children were followed-up monthly during treatment, then quarterly over 1 year. Costs of ..View full abstract
The study was funded by Expertise-France (Paris) and Agence Francaise de Developpement (Paris, France). The funding sources did not have any role in study design, in the collection, analysis, and interpretation of data, in the writing of the report, and in the decision to submit the paper for publication.