Journal article
Changes in inflammatory biomarkers are related to the antidepressant effects of Ayahuasca
NL Galvão-Coelho, AC de Menezes Galvão, RN de Almeida, F Palhano-Fontes, I Campos Braga, B Lobão Soares, JP Maia-de-Oliveira, D Perkins, J Sarris, DB de Araujo
Journal of Psychopharmacology | SAGE PUBLICATIONS LTD | Published : 2020
Abstract
Background: Ayahuasca is a traditional Amazon brew and its potential antidepressant properties have recently been explored in scientific settings. We conducted a double-blind placebo-controlled trial of ayahuasca with treatment-resistant depression patients (n = 28) and healthy controls (n = 45). Aims: We are evaluating the blood inflammatory biomarkers: C-reactive protein and interleukin 6, as a potential consequence of ayahuasca intake and their correlation with serum cortisol and brain-derived neurotrophic factor levels. Blood samples were collected at pre-treatment and 48 hours after substance ingestion to assess the concentration of inflammatory biomarkers, together with administration ..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by the Brazilian National Council for Scientific and Technological Development (CNPq, grants 466760/2014 and 479466/2013), CAPES Foundation within the Brazilian Ministry of Education (grants 1677/2012 and 1577/2013) and by National Science and Technology Institute for Translational Medicine (INCT-TM Fapesp 2014/50891-1; CNPq 465458/2014-9). NLGC is supported by CAPES Foundation from Brazilian Ministry of Education (Research Fellowship 88887.466701/2019-00). JS is supported by an NHMRC Clinical (Fellowship APP1125000).