Journal article

The ABC of Major Histocompatibility Complexes and T Cell Receptors in Health and Disease

Katherine Kedzierska, Marios Koutsakos

Viral Immunology | MARY ANN LIEBERT, INC | Published : 2020

Abstract

A seminal discovery of major histocompatibility complex (MHC) restriction in T cell recognition by Peter Doherty and Rolf Zinkernagel has led to 45 years of exciting research on the mechanisms governing peptide MHC (pMHC) recognition by T cell receptors (TCRs) and their importance in health and disease. T cells provide a significant level of protection against viral, bacterial, and parasitic infections, as well as tumors, hence, the generation of protective T cell responses is a primary goal for cell-mediated vaccines and immunotherapies. Understanding the mechanisms underlying generation of optimal high-avidity effector T cell responses, memory development, maintenance, and recall is of maj..

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