Journal article

Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients

Anoop N Koshy, Alexandra Murphy, Omar Farouque, Mark Horrigan, Matias B Yudi

Heart Lung and Circulation | ELSEVIER SCIENCE INC | Published : 2020


BACKGROUND: Transcatheter aortic valve replacement (TAVR) has revolutionised the treatment of severe aortic stenosis (AS), though its safety and efficacy in low-risk patients remains to be established. METHODS: A systematic review of PubMed, Medline and EMBASE identified four randomised controlled trials (RCTs) in patients at low surgical risk comparing TAVR to surgical aortic valve replacement (SAVR). A meta-analysis was performed with a primary outcome of a composite of all-cause mortality and stroke at longest available follow-up. RESULTS: A total of four RCTs with 2,836 patients was included in the final analysis. 1,363 patients were randomised to SAVR and 1,473 to TAVR. The composite of..

View full abstract


Awarded by Royal Australasian College of Physicians Blackburn Scholarship

Funding Acknowledgements

Dr A.M. is supported by the Cardiac Society of Australia and New Zealand PhD Scholarship. Dr A.N.K. is a recipient of the National Health and Medical Research Council of Australia/National Heart Foundation Post-Graduate Scholarship and Royal Australasian College of Physicians Blackburn Scholarship (1150874).