Journal article

Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients

Anoop N Koshy, Alexandra Murphy, Omar Farouque, Mark Horrigan, Matias B Yudi

Heart Lung and Circulation | ELSEVIER SCIENCE INC | Published : 2020

Abstract

BACKGROUND: Transcatheter aortic valve replacement (TAVR) has revolutionised the treatment of severe aortic stenosis (AS), though its safety and efficacy in low-risk patients remains to be established. METHODS: A systematic review of PubMed, Medline and EMBASE identified four randomised controlled trials (RCTs) in patients at low surgical risk comparing TAVR to surgical aortic valve replacement (SAVR). A meta-analysis was performed with a primary outcome of a composite of all-cause mortality and stroke at longest available follow-up. RESULTS: A total of four RCTs with 2,836 patients was included in the final analysis. 1,363 patients were randomised to SAVR and 1,473 to TAVR. The composite of..

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Grants

Awarded by Royal Australasian College of Physicians Blackburn Scholarship


Funding Acknowledgements

Dr A.M. is supported by the Cardiac Society of Australia and New Zealand PhD Scholarship. Dr A.N.K. is a recipient of the National Health and Medical Research Council of Australia/National Heart Foundation Post-Graduate Scholarship and Royal Australasian College of Physicians Blackburn Scholarship (1150874).