Vitamin D Induces Differential Effects on Inflammatory Responses During Bacterial and/or Viral Stimulation of Human Peripheral Blood Mononuclear Cells
Jeremy Anderson, Lien Anh Ha Do, Zheng Quan Toh, Edwin Hoe, Andrea Reitsma, Kim Mulholland, Paul V Licciardi
FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2020
Streptococcus pneumoniae (pneumococcus) and respiratory syncytial virus (RSV) are the leading causes of respiratory infections amongst children <5 years of age. Co-infection with these pathogens is common during early life and often associated with increased disease severity. Epidemiological studies have shown that low levels of Vitamin D3 (VitD3) are associated with increased susceptibility to respiratory pathogens. However, the role of VitD3 in the context of pneumococcal and RSV exposure are poorly understood. We found that VitD3 significantly reduced Th17 cell expression and IL-17A and IL-22 secretion in peripheral blood mononuclear cells (PBMCs) when stimulated with a pneumococcal whole..View full abstract
Awarded by Australian National Health and Medical Research Council Career Development Fellowship
PL is a recipient of an Australian National Health and Medical Research Council Career Development Fellowship (GNT1146198). The authors acknowledge the Victorian Government's Operational Infrastructure Support Program.