Journal article

Association between elevated cerebrospinal fluid D-dimer levels and delayed cerebral ischaemia after aneurysmal subarachnoid haemorrhage

Sujeevan Jayamanoharan, Jonathan E Mangum, Stanley Stylli, James Ziogas, Alexios A Adamides

Journal of Clinical Neuroscience | ELSEVIER SCI LTD | Published : 2020

Abstract

Delayed cerebral ischaemia (DCI) after aneurysmal subarachnoid haemorrhage (aSAH) is a major contributor to morbidity and mortality. It is currently not possible to reliably predict patients at risk of DCI after aSAH. The aim of this study was to quantify cerebrospinal fluid (CSF) D-Dimer and plasminogen levels and to investigate any association with development of DCI. Cerebrospinal fluid (CSF) samples collected from 30 patients within 72 h post-aSAH (n = 13 DCI and n = 17 non-DCI patients) were analysed. DCI was diagnosed when angiographic vasospasm was detected in the presence of new onset neurological deficit. Enzyme-linked immunosorbent assays were used to quantify D-dimer concentration..

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Grants

Funding Acknowledgements

SJ, AA and JZ acknowledge funding from JT Reid Charitable Trust and Neuroscience Foundation for materials used in this research.JM acknowledges Fellowship support from the Australian National Health and Medical Research Council.