Journal article

Cortical remodelling in childhood is associated with genes enriched for neurodevelopmental disorders

G Ball, J Seidlitz, R Beare, ML Seal



Cortical development during childhood and adolescence has been characterised in recent years using metrics derived from Magnetic Resonance Imaging (MRI). Changes in cortical thickness are greatest in the first two decades of life and recapitulate the genetic organisation of the cortex, highlighting the potential early impact of gene expression on differences in cortical architecture over the lifespan. It is important to further our understanding of the possible neurobiological mechanisms that underlie these changes as cortical thickness may be altered in several common neurodevelopmental and psychiatric disorders. In this study, we combine MRI acquired from a large typically-developing child..

View full abstract


Funding Acknowledgements

This research was conducted within the Developmental Imaging research group, Murdoch Childrens Research Institute and the Children's MRI Centre, Royal Children's Hospital, Melbourne, Victoria. It was supported by the Murdoch Childrens Research Institute, the Royal Children's Hospital, Department of Paediatrics, The University of Melbourne and the Victorian Government's Operational Infrastructure Support Program. The project was generously supported by RCH1000, a unique arm of The Royal Children's Hospital Foundation devoted to raising funds for research at The Royal Children's Hospital.Data and/or research tools used in the preparation of this manuscript were obtained and analysed from the controlled access datasets distributed from the NIMH-supported Research Domain Criteria Database (RDoCdb). RDoCdb is a collaborative informatics system created by the National Institute of Mental Health to store and share data resulting from grants funded through the Research Domain Criteria (RDoC) project. Dataset identifier(s): [DOI: 10.15154/1504093].