Journal article

Potential impact of family history-based screening guidelines on the detection of early-onset colorectal cancer

Samir Gupta, Balambal Bharti, Dennis J Ahnen, Daniel D Buchanan, Iona C Cheng, Michelle Cotterchio, Jane C Figueiredo, Steven J Gallinger, Robert W Haile, Mark A Jenkins, Noralane M Lindor, Finlay A Macrae, Loic Le Marchand, Polly A Newcomb, Stephen N Thibodeau, Aung Ko Win, Maria Elena Martinez

Cancer | WILEY | Published : 2020

Abstract

BACKGROUND: Initiating screening at an earlier age based on cancer family history is one of the primary recommended strategies for the prevention and detection of early-onset colorectal cancer (EOCRC), but data supporting the effectiveness of this approach are limited. The authors assessed the performance of family history-based guidelines for identifying individuals with EOCRC. METHODS: The authors conducted a population-based, case-control study of individuals aged 40 to 49 years with (2473 individuals) and without (772 individuals) incident CRC in the Colon Cancer Family Registry from 1998 through 2007. They estimated the sensitivity and specificity of family history-based criteria jointl..

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Grants

Awarded by National Cancer Institute (NCI) of the National Institutes of Health (NIH)


Awarded by VA HSRD


Awarded by Australasian Colorectal Cancer Family Registry


Awarded by Mayo Clinic Cooperative Family Registry for Colon Cancer Studies


Awarded by Ontario Familial Colorectal Cancer Registry


Awarded by Seattle Colorectal Cancer Family Registry


Awarded by University of Southern California Consortium Colorectal Cancer Family Registry


Awarded by University of Hawaii Colorectal Cancer Family Registry



Funding Acknowledgements

Supported by the National Cancer Institute (NCI) of the National Institutes of Health (NIH) under award NCI/NIH 5R37CA222866 (to Samir Gupta) and VA HSRD 5 I01 HX001574-04 (to Samir Gupta). Additional funding to the Colon Cancer Family Registry (CCFR) was provided under award U01CA167551 and through cooperative agreements with the following CCFR centers: Australasian Colorectal Cancer Family Registry (U01 CA074778 and U01/U24 CA097735), Mayo Clinic Cooperative Family Registry for Colon Cancer Studies (U01/U24 CA074800), Ontario Familial Colorectal Cancer Registry (U01/U24 CA074783), Seattle Colorectal Cancer Family Registry (U01/U24 CA074794), University of Hawaii Colorectal Cancer Family Registry (U01/U24 CA074806 and R01 CA104132), and University of Southern California Consortium Colorectal Cancer Family Registry (U01/U24 CA074799). The content of this article does not necessarily reflect the views or policies of the NCI or any of the collaborating centers in the CCFR, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government or the CCFR.