Journal article

IgM( )memory B cells induced in response toPlasmodium bergheiadopt a germinal centre B cell phenotype during secondary infection

Halina M Pietrzak, Lisa J Ioannidis, Diana S Hansen

Parasitology | CAMBRIDGE UNIV PRESS | Published : 2020

Abstract

Emerging evidence started to delineate multiple layers of memory B cells, with distinct effector functions during recall responses. Whereas most studies examining long-lived memory B cell responses have focussed on the IgG+ memory B cell compartment, IgM+ memory B cells have only recently started to receive attention. It has been proposed that unlike IgG+ memory B cells, which differentiate into antibody-secreting plasma cells upon antigen re-encounter, IgM+ memory B cells might have the additional capacity to establish secondary germinal centre (GC) responses. The precise function of IgM+ memory B cells in the humoral immune response to malaria has not been fully defined. Using a murine mod..

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University of Melbourne Researchers

Grants

Awarded by Australian Government National Health and Medical Research Council IRIISS


Funding Acknowledgements

This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government National Health and Medical Research Council IRIISS, Project Grant 1058665 and the Australian Academy of Science Regional Collaboration Grant. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.