Journal article

Neurovegetative symptom subtypes in young people with major depressive disorder and their structural brain correlates

Yara J Toenders, Lianne Schmaal, Ben J Harrison, Richard Dinga, Michael Berk, Christopher G Davey

TRANSLATIONAL PSYCHIATRY | NATURE PUBLISHING GROUP | Published : 2020

Abstract

Depression is a leading cause of burden of disease among young people. Current treatments are not uniformly effective, in part due to the heterogeneous nature of major depressive disorder (MDD). Refining MDD into more homogeneous subtypes is an important step towards identifying underlying pathophysiological mechanisms and improving treatment of young people. In adults, symptom-based subtypes of depression identified using data-driven methods mainly differed in patterns of neurovegetative symptoms (sleep and appetite/weight). These subtypes have been associated with differential biological mechanisms, including immuno-metabolic markers, genetics and brain alterations (mainly in the ventral s..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by NHMRC


Awarded by The Netherlands Brain Foundation


Funding Acknowledgements

This study was supported by the National Health and Medical Research Council of Australia (NHMRC) Project Grants to C.G.D. (YoDA C ID 1024570), M.B. (YoDA A ID 1027315) and B.J.H. (1064643). B.J.H. is supported by a NHMRC Career Development Fellowship (1124472). C.G.D. is supported by an NHMRC Career Development Award (141738). M.B. is supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (APP1059660 and APP1156072). L.S. is supported by a NHMRC Career Development Fellowship (1140764) and gratefully acknowledges support from The Netherlands Brain Foundation (F2014[1]-24) for this work.