Journal article
Fungal Trans-kingdom Dynamics Linked to Responsiveness to Fecal Microbiota Transplantation (FMT) Therapy in Ulcerative Colitis
I Leonardi, S Paramsothy, I Doron, A Semon, NO Kaakoush, JC Clemente, JJ Faith, TJ Borody, HM Mitchell, JF Colombel, MA Kamm, ID Iliev
Cell Host and Microbe | CELL PRESS | Published : 2020
Abstract
Leonardi et al. show that high burdens of intestinal Candida prior to FMT are associated with an increased responsiveness to FMT in ulcerative colitis patients in a multi-center, double-blind, randomized, placebo-controlled trial. These results suggest that FMT might reduce Candida abundance and restrict pro-inflammatory immunity during intestinal inflammation.
Grants
Awarded by National Institutes of Health
Funding Acknowledgements
Research in the Iliev laboratory is supported by the US National Institutes of Health (DK113136, DK121977 and AI137157), the Crohn's and Colitis Foundation Senior Research Award, the Helmsley Charitable Trust, the Irma T. Hirschl Career Scientist Award, pilot funding from the Center for Advanced Digestive Care (CADC), and the JRI for research in IBD. J.F.C. is supported by the Cutting-Edge Therapies for Ulcerative Colitis grant; H.M.M. is supported by a Lit-win IBD Pioneer Award from Crohn's and Colitis Foundation; I.L. is supported by fellowships from the Crohn's and Colitis Foundation.