Journal article

Perineural invasion by prostate adenocarcinoma in needle biopsies predicts bone metastasis: Ten year data from the TROG 03.04 RADAR Trial

Brett Delahunt, Judith D Murray, Allison Steigler, Chris Atkinson, David Christie, Gillian Duchesne, Lars Egevad, David Joseph, John Matthews, Christopher Oldmeadow, Hemamali Samaratunga, Nigel A Spry, John R Srigley, Hubert Hondermarck, James W Denham

Histopathology | WILEY | Published : 2020

Abstract

AIMS: Perineural invasion (PNI) by prostatic adenocarcinoma is debated as a prognostic parameter. This study investigates the prognostic predictive value of PNI in a series of patients with locally advanced prostate cancer treated with radiotherapy and androgen deprivation using 10 year outcome data from the TROG 03.04 RADAR trial. METHODS: Diagnostic prostate biopsies from 976 patients were reviewed and the presence of PNI noted. Patients were followed for 10 years according to the trial protocol or until death. The primary endpoint for the study was time to bone metastasis. Secondary endpoints included time to soft tissue metastasis, transition to castration resistance, prostate cancer-spe..

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