Journal article

Body Composition in Young Adults Living With a Fontan Circulation: The Myopenic Profile

Derek Tran, Paolo D'Ambrosio, Charlotte E Verrall, Chantal Attard, Julie Briody, Mario D'Souza, Maria Fiatarone Singh, Julian Ayer, Yves d'Udekem, Stephen Twigg, Glen M Davis, David S Celermajer, Rachael Cordina

Journal of the American Heart Association | WILEY | Published : 2020


Background We sought to characterize body composition abnormalities in young patients living with a Fontan circulation and explore potential pathophysiologic associations. Methods and Results Twenty-eight patients with a Fontan circulation were prospectively recruited in this cross-sectional study. Participants underwent cardiopulmonary exercise testing, dual-energy X-ray absorptiometry, echocardiography, and biochemical assessment. Mean age was 26±7 years. Skeletal muscle mass, estimated by appendicular lean mass index Z score, was reduced compared with reference data (-1.49±1.10, P<0.001). Percentage body fat Z score overall was within normal range (0.23±1.26, P=0.35), although 46% had ele..

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