Journal article

Body Composition in Young Adults Living With a Fontan Circulation: The Myopenic Profile

Derek Tran, Paolo D'Ambrosio, Charlotte E Verrall, Chantal Attard, Julie Briody, Mario D'Souza, Maria Fiatarone Singh, Julian Ayer, Yves d'Udekem, Stephen Twigg, Glen M Davis, David S Celermajer, Rachael Cordina

Journal of the American Heart Association | WILEY | Published : 2020


Background We sought to characterize body composition abnormalities in young patients living with a Fontan circulation and explore potential pathophysiologic associations. Methods and Results Twenty-eight patients with a Fontan circulation were prospectively recruited in this cross-sectional study. Participants underwent cardiopulmonary exercise testing, dual-energy X-ray absorptiometry, echocardiography, and biochemical assessment. Mean age was 26±7 years. Skeletal muscle mass, estimated by appendicular lean mass index Z score, was reduced compared with reference data (-1.49±1.10, P<0.001). Percentage body fat Z score overall was within normal range (0.23±1.26, P=0.35), although 46% had ele..

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by a National Health and Medical Research Council project grant 1065794, "Functional Outcomes After Fontan Surgery," and National Health and Medical Research Council partnership grant 1076849, "Giving an Adult Life After Fontan Surgery to Those With the Most Severe Congenital Heart Conditions."