Differential Effects of Long-Term Caloric Restriction and Dietary Protein Source on Bone and Marrow Fat of the Aging Rat
Gustavo Duque, Ahmed Al Saedi, Daniel Rivas, Stephanie Miard, Guylaine Ferland, Frederic Picard, Pierrette Gaudreau
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | OXFORD UNIV PRESS INC | Published : 2020
Long-term caloric restriction (CR) has been shown to be beneficial to various tissues and organs. In contrast, CR exerts differential effects on bone, which could be due in part to the nature of the protein regime utilized. Male Sprague Dawley rats (8-month-old) were subjected for 12 months to 40% CR in macronutrients and compared with rats fed ad libitum for the same period. Casein- and soy-fed groups were compared. There was a significant decrease in bone quality in both CR groups, which was independent of the source of protein in the diet. In contrast, the group fed soy protein ad libitum showed better bone quality and higher levels of bone formation compared with casein-fed animals. Nota..View full abstract
Awarded by Canadian Institutes of Health Research (CIHR)
This work was supported by a catalyst grant on aging research from the Canadian Institutes of Health Research (CIHR; 200703IAP to G.D., G.F., P.G., and F.P.) and a pilot project grant from the Quebec Network for Research on Aging, a network funded by the Fonds de Recherche du Quebec-Sante.