Journal article

Repetitive Mild Traumatic Brain Injury Alters Glymphatic Clearance Rates in Limbic Structures of Adolescent Female Rats

Jennaya Christensen, David K Wright, Glenn R Yamakawa, Sandy R Shultz, Richelle Mychasiuk



The glymphatic system is the macroscopic waste clearance system for the central nervous system. Glymphatic dysfunction has been linked to several neurological conditions, including traumatic brain injury (TBI). Adolescents are at particularly high risk for experiencing a TBI, particularly mild TBI (mTBI) and repetitive mTBI (RmTBI); however, glymphatic clearance, and how it relates to behavioral outcomes, has not been investigated in this context. Therefore, this study examined glymphatic function in the adolescent brain following RmTBI. Female adolescent Sprague Dawley rats were subjected to either three mTBIs or sham injuries spaced three days apart. One-day after their final injury, the a..

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Funding Acknowledgements

The authors would like to thank the Alberta Children's Hospital Research Institute, Canadian Institute of Health Research, Natural Sciences and Engineering Research Council, and National Health and Medical Research Council for their financial contributions. The authors would also like to thank Tadeusz Foniok and Dave Rushforth for their assistance within the University of Calgary MRI facility. The authors have no competing financial interests with respect to the work described here.