Book Chapter

Modeling and remodeling: The cellular machinery responsible for bone’s material and structural strength during growth, aging, and drug therapy

E Seeman

Principles of Bone Biology | Elsevier | Published : 2020

Abstract

Bone modeling and remodeling assemble bone’s structure during growth. Abnormalities in this cellular machinery appear around midlife and cause microstructural deterioration and bone fragility. For over 60years, the gain and loss of bone strength have been inferred by measuring bone mineral density (BMD). This is an insensitive surrogate of bone fragility caused by microstructural deterioration, because microstructural deterioration compromises strength disproportionate to the bone loss producing it and the modest deficits in BMD found in most patients with fragility fractures. Quantification of microstructure is now available, but whether these measurements improve the detection of individua..

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University of Melbourne Researchers

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