The Nexus Between Periodontal Inflammation and Dysbiosis
Thomas E Van Dyke, P Mark Bartold, Eric C Reynolds
Frontiers in Immunology | FRONTIERS MEDIA SA | Published : 2020
The nexus between periodontal inflammation and the polymicrobial biofilm in the gingival sulcus is critical to understanding the pathobiology of periodontitis. Both play a major role in the etiology and pathogenesis of periodontal diseases and each reinforces the other. However, this nexus is also at the center of a significant conundrum for periodontology. For all mucosal polymicrobial biofilms, the most confounding issue is the paradoxical relationship between inflammation, infection, and disease. Despite significant advances made in both periodontal microbiology and periodontal pathobiology, the issue of which comes first, the inflammatory response or the change to a dysbiotic subgingival..View full abstract
Awarded by USPHS from NIDCR
This work was supported in part by USPHS grants DE025020 and DE025383 from NIDCR (TV).