Journal article

Impact of CYP2C19 genotype-predicted enzyme activity on hippocampal volume, anxiety, and depression.

Aisouda Savadlou, Aurina Arnatkeviciute, Jeggan Tiego, Ziarih Hawi, Mark A Bellgrove, Alex Fornito, Chad Bousman

Psychiatry Res | Published : 2020

Abstract

Cytochrome P450 C19 (CYP2C19) metabolizes exogenous and endogenous compounds. Although CYP2C19 is highly expressed in the liver, it is also expressed in the brain during early life. Previous human and animal studies have linked CYP2C19 genotype-predicted enzyme activity to hippocampal volumes, depressive symptoms, and anxiety-like behaviors. We examined these promising associations in a general community sample comprising 386 Caucasian adults with no history of psychiatric or neurological illnesses. Contrary to previous findings, CYP2C19 genotype-predicted enzyme activity was not associated with hippocampal volumes, nor depressive and anxiety symptoms. Interstudy differences in CYP2C19 frequ..

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University of Melbourne Researchers