Journal article

Three-tissue compositional analysis reveals in-vivo microstructural heterogeneity of white matter hyperintensities following stroke

Wasim Khan, Natalia Egorova, Mohamed Salah Khlif, Remika Mito, Thijs Dhollander, Amy Brodtmann

NeuroImage | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2020

Abstract

White matter hyperintensities (WMHs) are frequently observed on brain scans of older individuals and are associated with cognitive impairment and vascular brain burden. Recent studies have shown that WMHs may only represent an extreme end of a diffuse pathological spectrum of white matter (WM) degeneration. The present study investigated the microstructural characteristics of WMHs using an advanced diffusion MRI modelling approach known as Single-Shell 3-Tissue Constrained Spherical Deconvolution (SS3T-CSD), which provides information on different tissue compartments within each voxel. The SS3T-CSD method may provide complementary information in the interpretation of pathological tissue thro..

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