Three-tissue compositional analysis reveals in-vivo microstructural heterogeneity of white matter hyperintensities following stroke
Wasim Khan, Natalia Egorova, Mohamed Salah Khlif, Remika Mito, Thijs Dhollander, Amy Brodtmann
NeuroImage | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2020
White matter hyperintensities (WMHs) are frequently observed on brain scans of older individuals and are associated with cognitive impairment and vascular brain burden. Recent studies have shown that WMHs may only represent an extreme end of a diffuse pathological spectrum of white matter (WM) degeneration. The present study investigated the microstructural characteristics of WMHs using an advanced diffusion MRI modelling approach known as Single-Shell 3-Tissue Constrained Spherical Deconvolution (SS3T-CSD), which provides information on different tissue compartments within each voxel. The SS3T-CSD method may provide complementary information in the interpretation of pathological tissue thro..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) Dementia Research Team Grant at the Florey Institute of Neuroscience and Mental Health, Melbourne, Australia
This work is supported by the National Health and Medical Research Council (NHMRC) Dementia Research Team Grant (APP1094974) at the Florey Institute of Neuroscience and Mental Health, Melbourne, Australia.