Translational Potential of Non-coding RNAs for Cardiovascular Disease
Jenny YY Ooi, Bianca C Bernardo, J Xiao
Advances in experimental medicine and biology | SPRINGER-VERLAG SINGAPORE PTE LTD | Published : 2020
Heart failure is the end result of a variety of cardiovascular disease states. Heart failure remains a challenge to treat, and the incidence continues to rise with an aging population, and increasing rates of diabetes and obesity. Non-coding RNAs, once considered as "junk DNA", have emerged as powerful transcriptional regulators and potential therapeutic targets for the treatment of heart failure. Different classes of non-coding RNAs exist, including small non-coding RNAs, referred to as microRNAs, and long non-coding RNAs. Both microRNAs and long non-coding RNAs play a role in cardiac development as well as in the pathogenesis of cardiovascular disease, prompting many studies to investigate..View full abstract
The authors would like to thank Julie R. McMullen at Baker Heart & Diabetes Institute for proofreading the manuscript. The authors acknowledge funding support from the Sir Edward Dunlop Medical Research Foundation (to J.Y.Y.O and B.C.B). B.C.B is supported by an Alice Baker and Eleanor Shaw Fellowship (The Baker Foundation, Melbourne, Australia).