Journal article
Candidate gene expression in response to low-level air pollution
L Madaniyazi, S Li, S Li, Y Guo
Environment International | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2020
Open access
Abstract
Background: Epidemiological studies have linked air pollutant to adverse health effects even at low exposure levels, but limited evidence is available on its associations with gene expression levels. Aim: To investigate associations between air pollutants and gene expression levels. Methods: We collected data from Brisbane System Genetics Study (BSGS) — a family-based system genetics study. Expression levels of candidate genes were obtained for whole blood from 266 pairs of twins (192 monozygotic and 74 dizygotic pairs) and 165 parents. Data on individual phenotypes were also obtained, including age, sex, Body Mass Index and exposure to smoke. Daily data on mean temperature and air pollutant..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
We thank A/Prof Joseph Powell from Garvan Institute of Medical Research for providing the data and also for his comments on this manuscript. Lina Madaniyazi was supported by Supporting Overseas Travel Expenses to Young Researchers contributing to Global Health 2019 from School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan. Shanshan Li was supported by an Early Career Fellowship of the Australian National Health and Medical Research Council (number APP1109193). Yuming Guo was supported by Career Development Fellowships of the Australian National Health and Medical Research Council (numbers APP1107107 and APP1163693).