Journal article

Extreme disruption of heterochromatin is required for accelerated hematopoietic aging

Christine R Keenan, Nadia Iannarella, Gaetano Naselli, Naiara G Bediaga, Timothy M Johanson, Leonard C Harrison, Rhys S Allan

BLOOD | AMER SOC HEMATOLOGY | Published : 2020

Abstract

Loss of heterochromatin has been proposed as a universal mechanism of aging across different species and cell types. However, a comprehensive analysis of hematopoietic changes caused by heterochromatin loss is lacking. Moreover, there is conflict in the literature around the role of the major heterochromatic histone methyltransferase Suv39h1 in the aging process. Here, we use individual and dual deletion of Suv39h1 and Suv39h2 enzymes to examine the causal role of heterochromatin loss in hematopoietic cell development. Loss of neither Suv39h1 nor Suv39h2 individually had any effect on hematopoietic stem cell function or the development of mature lymphoid or myeloid lineages. However, deletio..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Australian Research Council


Funding Acknowledgements

This work was supported by grants and fellowships from the National Health and Medical Research Council of Australia, 1125436 (C.R.K.), 1124081 (T.M.J.), 1080887 (L.C.H.), 1100451 (R.S.A.), and the Australian Research Council grant 130100541 (R.S.A.). This study was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC Independent Research Institute Infrastructure Support scheme and the Australian Cancer Research Fund.