Journal article

Malaria in Pregnancy Interacts with and Alters the Angiogenic Profiles of the Placenta

Ricardo Ataide, Oscar Murillo, Jamille G Dombrowski, Rodrigo M Souza, Flavia A Lima, Giselle FMC Lima, Angelica D Hristov, Suiane CN Valle, Silvia M Di Santi, Sabrina Epiphanio, Claudio RF Marinho

PLoS Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2015

Abstract

Malaria in pregnancy remains a substantial public health problem in malaria-endemic areas with detrimental outcomes for both the mother and the foetus. The placental changes that lead to some of these detrimental outcomes have been studied, but the mechanisms that lead to these changes are still not fully elucidated. There is some indication that imbalances in cytokine cascades, complement activation and angiogenic dysregulation might be involved in the placental changes observed. Nevertheless, the majority of studies on malaria in pregnancy (MiP) have come from areas where malaria transmission is high and usually restricted to Plasmodium falciparum, the most pathogenic of the malaria parasi..

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University of Melbourne Researchers

Grants

Awarded by Conselho Nacional de Desenvolvimento Cientifico e Tecnologico CNPq


Awarded by Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior CAPES


Awarded by Fundacao de Apoio a Pesquisa do Estado de Sao Paulo FAPESP


Awarded by FAPESP


Awarded by Universidade Federal do Acre


Funding Acknowledgements

Financial support was provided by Fundacao de Apoio a Pesquisa do Estado de Sao Paulo FAPESP (Grant no 2009/53889-0 and 2009/53256-7); Conselho Nacional de Desenvolvimento Cientifico e Tecnologico CNPq (Grant no 404213/2012 and 475103/2013-0) and Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior CAPES (Grant no AUX-PE-PNPD 2751/2010). RA and JGD were supported by FAPESP (fellowship no 2011/20921-8 and 2012/04755-3); RMS was supported by Universidade Federal do Acre and CNPq (fellowship no 141946/2012-1). CRFM is enrolled at the Programa Estrategico de Ciencia, Tecnologia & Inovacao nos Programas de PosGraduacao do Estado do Amazonas (PECTI/AM-PG) from Fundacao de Amparo a Pesquisa do Estado do Amazonas (FAPEAM, Brazil). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.