Journal article

ENIGMA-DTI: Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research

Peter Kochunov, L Elliot Hong, Emily L Dennis, Rajendra A Morey, David F Tate, Elisabeth A Wilde, Mark Logue, Sinead Kelly, Gary Donohoe, Pauline Favre, Josselin Houenou, Christopher RK Ching, Laurena Holleran, Ole A Andreassen, Laura S van Velzen, Lianne Schmaal, Julio E Villalon-Reina, Carrie E Bearden, Fabrizio Piras, Gianfranco Spalletta Show all

HUMAN BRAIN MAPPING | WILEY | Published : 2020

Abstract

The ENIGMA-DTI (diffusion tensor imaging) workgroup supports analyses that examine the effects of psychiatric, neurological, and developmental disorders on the white matter pathways of the human brain, as well as the effects of normal variation and its genetic associations. The seven ENIGMA disorder-oriented working groups used the ENIGMA-DTI workflow to derive patterns of deficits using coherent and coordinated analyses that model the disease effects across cohorts worldwide. This yielded the largest studies detailing patterns of white matter deficits in schizophrenia spectrum disorder (SSD), bipolar disorder (BD), major depressive disorder (MDD), obsessive-compulsive disorder (OCD), posttr..

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Grants

Awarded by National Institutes of Health


Awarded by NIMH


Awarded by NIH Big Data to Knowledge (BD2K) program under consortium


Awarded by ENIGMA World Aging Center


Awarded by ENIGMA Sex Differences Initiative


Awarded by ENIGMA-PGC PTSD Working Group


Awarded by ENIGMA Epilepsy Working Group


Awarded by NIH


Awarded by ENIGMA-COINSTAC: Advanced Worldwide Transdiagnostic Analysis of Valence System Brain Circuits


Awarded by Italian Ministry of Health


Awarded by ENIGMA's NIH Big Data to Knowledge (BD2K) initiative


Awarded by T32 Postdoctoral Scholar Fellowship Trainee Grant


Awarded by NIA


Awarded by Research Council of Norway


Awarded by South-East Norway Health Authority


Awarded by Kristian Gerhard Jebsen Stiftelsen


Awarded by NIH/NIMH


Awarded by European Research Council


Awarded by Science Foundation Ireland


Awarded by Health Research Board


Awarded by NHMRC


Awarded by VA BLRD


Awarded by Department of Defense, Chronic Effects of Neurotrauma Consortium (CENC)


Awarded by Santa Lucia Foundation in Rome, Italy - Italian Ministry of Health


Awarded by Dutch Research Council



Funding Acknowledgements

Support was received from the National Institutes of Health grants: R01MH111671, R01MH112180, R01MH116948, S10OD023696, 5T32MH073526, R01EB015611, U01MH108148, and NIMH R01085953 (CEB), R21 MH116473 (CEB), and R01MH117601. Core funding for ENIGMA was provided by the NIH Big Data to Knowledge (BD2K) program under consortium grant U54 EB020403 (PI: Thompson). Additional support was provided by grants to the ENIGMA World Aging Center (R56 AG058854; PI: Thompson), the ENIGMA Sex Differences Initiative (R01 MH116147; PI: Thompson), the ENIGMA-PGC PTSD Working Group (R01 MH111671; PI: Morey), the ENIGMA Epilepsy Working Group (R01 NS107739; to McDonald), a Kavli Foundation Neuroscience without Borders seed grant (to Jahanshad and Thompson), an NIH instrumentation grant (S10 OD023696 to Kochunov), and ENIGMA-COINSTAC: Advanced Worldwide Transdiagnostic Analysis of Valence System Brain Circuits (1R01MH121246-01, to Turner, Calhoun, and van Erp). Support was also provided by the Italian Ministry of Health, grant RC 15-16-17-18-19/A, Fondation pour la recherche medicale "Bioinformatics for Biology 2014" grant. These funding sources provided financial support to enable design and conduct of the study and collection, management, and analysis of the data. None of the funding agencies had a role in the interpretation of the data. None had a role in the preparation, review, or approval of the manuscript. None had a role in the decision to submit the manuscript for publication. N.J. is supported by R01 AG059874 and R01 MH117601 (to N.J. and L.S.). C.R.K.C. is supported by ENIGMA's NIH Big Data to Knowledge (BD2K) initiative U54 EB020403, T32 Postdoctoral Scholar Fellowship Trainee Grant 5251831121, NIA T32AG058507. O.A.A. is supported by Research Council of Norway (223273, 248778, 248980, 249711), South-East Norway Health Authority (2019108), and the Kristian Gerhard Jebsen Stiftelsen (SKGJ-MED-008). C.E.B. is supported by NIH/NIMH grant R01 MH085953, NIH/NIMH grant R01 MH100900, ENIGMA's NIH Big Data to Knowledge (BD2K) initiative U54 EB020403, and SFARI Explorer Award. G.D. is supported by funding from the European Research Council (ERC677467), Science Foundation Ireland (16ERCS3787), and the Health Research Board (CDA-2018-001). T.G.M.v.E. is supported by ENIGMA's NIH Big Data to Knowledge (BD2K) initiative U54 EB020403, ENIGMA Sex Differences R01MH116147, and ENIGMA-COINSTAC: Advanced Worldwide Transdiagnostic Analysis of Valence System Brain Circuits R01MH121246. L.S. is supported by a NHMRC Career Development Fellowship (1140764) and R01 MH117601 (to N.J. and L.S.). M.W.L. is supported by VA BLR&D I01BX003477 (PI: Logue), R01-MH111671 (PI: Morey). E.L.D. is supported by K99NS096116. D.F.T. is supported by Chronic Effects of Neurotrauma Consortium. E.A.W. is supported by the Department of Defense, Chronic Effects of Neurotrauma Consortium (CENC) Award W81XWH-13-2-0095, 5 I01 RX002174. D.J.S. is supported by the South African Medical Research Council. F.P. is supported from the Santa Lucia Foundation in Rome, Italy are funded by the Italian Ministry of Health grants RC12-13-14-15-16-17-18-19/A. J.E.V.-R. is supported by ENIGMA's NIH Big Data to Knowledge (BD2K) initiative U54 EB020403. O.A.v. d.H. is supported by the Dutch Research Council (VIDI grant 91717306).