Journal article

Host CD8 alpha( ) and CD103( ) dendritic cells prime transplant antigen-specific CD8( ) T cells via cross-dressing

Bin Li, Chunni Lu, Sara Oveissi, Jing Song, Kun Xiao, Damien Zanker, Mubin Duan, Jianxin Chen, Huji Xu, Quanming Zou, Chao Wu, Jonathan W Yewdell, Weisan Chen

Immunology & Cell Biology | WILEY | Published : 2020


The participation of dendritic cells (DCs) in CD8+ T-cell-mediated allograft rejection is a long-standing question of great clinical relevance for tissue transplantation. Here, we show that Batf3-/- mice demonstrate delayed allo-skin graft rejection and are deficient in priming allo-specific CD8+ T cells. Batf3-/- mouse priming is restored by transferring either purified CD8α+ or CD103+ DCs, demonstrating the critical role of these cells in alloreactivity. Using Db -restricted antiviral F5 transgenic T-cell receptor T cells, which we demonstrate are alloreactive with H-2Kd , we show that cross-dressing of CD8α+ and CD103+ primes CD8+ T-cell or allo-specific responses in vitro and in vivo. Th..

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Awarded by NHMRC program

Funding Acknowledgements

This project was partly supported by the NHMRC program grant 567122 to WC. BL was supported by a scholarship from China Scholarship Council. JWY is supported by the DIR, NIAID, NIH.