Journal article
DNA Methylation Patterns in Rat Mammary Carcinomas Induced by Pre- and Post-Pubertal Irradiation
Masaru Takabatake, Benjamin J Blyth, Kazuhiro Daino, Tatsuhiko Imaoka, Mayumi Nishimura, Masahiro Fukushi, Yoshiya Shimada
PLoS One | Public Library of Science (PLoS) | Published : 2016
Open access
Abstract
Several lines of evidence indicate one's age at exposure to radiation strongly modifies the risk of radiation-induced breast cancer. We previously reported that rat mammary carcinomas induced by pre- and post-pubertal irradiation have distinct gene expression patterns, but the changes underlying these differences have not yet been characterized. The aim of this investigation was to see if differences in CpG DNA methylation were responsible for the differences in gene expression between age at exposure groups observed in our previous study. DNA was obtained from the mammary carcinomas arising in female Sprague-Dawley rats that were either untreated or irradiated (γ-rays, 2 Gy) during the pre-..
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Awarded by Japan Society for the Promotion of Science
Funding Acknowledgements
This work was supported in part by Grants-in-Aid for the Third Comprehensive 10-year Strategy for Cancer Control and for Cancer Research from the Ministry of Health, Labor, and Welfare of Japan (http://www.mhlw.go.jp) to KD, and for the Japan Society for the Promotion of Science Fellows (https.//www.jsps.go.jp) to MT (No. 24-7555). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.