Journal article

Novel alterations in corneal neuroimmune phenotypes in mice with central nervous system tauopathy

Haihan Jiao, Laura E Downie, Xin Huang, Mengliang Wu, Sara Oberrauch, Ryan J Keenan, Laura H Jacobson, Holly R Chinnery

Journal of Neuroinflammation | BMC | Published : 2020

Abstract

BACKGROUND: Tauopathy in the central nervous system (CNS) is a histopathological hallmark of frontotemporal dementia (FTD) and Alzheimer's disease (AD). Although AD is accompanied by various ocular changes, the effects of tauopathy on the integrity of the cornea, which is densely innervated by the peripheral nervous system and is populated by resident dendritic cells, is still unknown. The aim of this study was to investigate if neuroimmune interactions in the cornea are affected by CNS tauopathy. METHODS: Corneas from wild type (WT) and transgenic rTg4510 mice that express the P301L tau mutation were examined at 2, 6, 8, and 11 months. Clinical assessment of the anterior segment of the eye ..

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Grants

Awarded by NHMRC


Funding Acknowledgements

University of Melbourne Medicine, Dentistry and Health Sciences Seed Funding (H.R.C, L.H.J and L.E.D), University of Melbourne Early Career Researcher Grant (H.J), and NH&MRC Project Grant APP1126540 (H.R.C)