Journal article

Personality factors and cerebral glucose metabolism in community-dwelling older adults

Hamid R Sohrabi, Kathryn Goozee, Michael Weinborn, Kaikai Shen, Belinda M Brown, Stephanie R Rainey-Smith, Olivier Salvado, Kevin Taddei, Romola S Bucks, Paul Maruff, Simon M Laws, Nat Lenzo, Manja Laws, Colin DeYoung, Craig Speelman, Christoph Laske, David Ames, Greg Savage, Ralph N Martins

Brain Structure and Function | SPRINGER HEIDELBERG | Published : 2020


Personality factors have been associated with Alzheimer's disease (AD) and dementia, but they have not been examined against markers of regional brain glucose metabolism (a primary measure of brain functioning) in older adults without clinically diagnosed cognitive impairment. The relationship between personality factors derived from the five-factor model and cerebral glucose metabolism determined using positron emission tomography (PET) with [18F]-2-fluoro-2-deoxy-D-glucose (18F-FDG-PET) was examined in a cohort of 237 non-demented, community-dwelling older adults aged 60-89 years (M ± SD = 73.76 ± 6.73). Higher neuroticism and lower scores on extraversion and conscientiousness were signifi..

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Awarded by National Health and Medical Research Council of Australia

Awarded by Edith Cowan University

Funding Acknowledgements

The WA Memory Study (WAMS) was supported by the National Health and Medical Research Council of Australia (Grant Number: 324100 awarded to RNM), an Early Career Researcher Grant from Edith Cowan University (HRS; G1001512-2014), the Australian Alzheimer's Research Foundation Inc., and the McCusker Charitable Foundation. The KARVIAH Study was supported by the Australian Alzheimer's Research Foundation and the Foundation for Aged Care, Anglicare, Sydney, Australia. The authors would like to thank the WAMS and KARVIAH Study participants and research assistants and volunteers, without whose contribution this research would not be possible.