Assessment of conditioned fear extinction in male and female adolescent rats
Christina J Perry, Despina E Ganella, Dao Nguyen Ly, Xin Du, Katherine D Drummond, Sarah Whittle, Terence Y Pang, Jee Hyun Kim
Psychoneuroendocrinology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2020
Pavlovian fear conditioning and extinction have been widely studied across many species to understand emotional learning and memory. Importantly, it is becoming clear that these processes are affected by sex and age. In adult rodents and humans, sex differences are evident in extinction, with estradiol playing a significant role. In adolescence, an extinction deficit has been reported in rodents and humans. However, the influence of sex on extinction during adolescence is unknown. This is surprising, since adolescence coincides with the onset of hormone cycling, and therefore it might be expected that hormones fluctuations exert a more profound effect at this time. Therefore, we examined Pav..View full abstract
This work was supported by National Health and Medical Research Council (NHMRC)/Australian Research Council Dementia Research Development Fellowships awarded to CJP and XD, Baker Foundation Fellowship awarded to DEG, NHMRC project grant awarded to TYP, NHMRC Career Development Fellowships awarded to JHK and SW, and the Victorian State Government Operational Infrastructure Scheme. The authors declare that they do not have any conflicts of interest (financial or otherwise) related to the data presented in this manuscript.