[F-18]THK5351 PET Imaging in Patients with Mild Cognitive Impairment
Hye Jin Jeong, Hyon Lee, Sang-Yoon Lee, Seongho Seo, Kee Hyung Park, Yeong-Bae Lee, Dong Jin Shin, Jae Myeong Kang, Byeong Kil Yeon, Seung-Gul Kang, Jaelim Cho, Joon-Kyung Seong, Nobuyuki Okamura, Victor L Villemagne, Duk L Na, Young Noh
Journal of Clinical Neurology | KOREAN NEUROLOGICAL ASSOC | Published : 2020
BACKGROUND AND PURPOSE: Mild cognitive impairment (MCI) is a condition with diverse clinical outcomes and subgroups. Here we investigated the topographic distribution of tau in vivo using the positron emission tomography (PET) tracer [¹⁸F]THK5351 in MCI subgroups. METHODS: This study included 96 participants comprising 38 with amnestic MCI (aMCI), 21 with nonamnestic MCI (naMCI), and 37 with normal cognition (NC) who underwent 3.0-T MRI, [¹⁸F]THK5351 PET, and detailed neuropsychological tests. [¹⁸F]flutemetamol PET was also performed in 62 participants. The aMCI patients were further divided into three groups: 1) verbal-aMCI, only verbal memory impairment; 2) visual-aMCI, only visual memory ..View full abstract
Awarded by Korea Healthcare Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare of the Republic of Korea
Awarded by Brain Research Program of the National Research Foundation (NRF) - Korean government (MSIT)
This study was supported by a grant from the Korea Healthcare Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare of the Republic of Korea (grant No: HI14C1135), and by the Brain Research Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) (No. 2018M3C7A1056889).