Journal article
[18F]THK5351 PET imaging in patients with mild cognitive impairment
HJ Jeong, H Lee, SY Lee, S Seo, KH Park, YB Lee, DJ Shin, JM Kang, BK Yeon, SG Kang, J Cho, JK Seong, N Okamura, VL Villemagne, DL Na, Y Noh
Journal of Clinical Neurology Korea | KOREAN NEUROLOGICAL ASSOC | Published : 2020
Open access
Abstract
Background and Purpose Mild cognitive impairment (MCI) is a condition with diverse clinical outcomes and subgroups. Here we investigated the topographic distribution of tau in vivo using the positron emission tomography (PET) tracer [18F]THK5351 in MCI subgroups. Methods This study included 96 participants comprising 38 with amnestic MCI (aMCI), 21 with nonamnestic MCI (naMCI), and 37 with normal cognition (NC) who underwent 3.0-T MRI, [18F]THK5351 PET, and detailed neuropsychological tests. [18F]flutemetamol PET was also performed in 62 participants. The aMCI patients were further divided into three groups: 1) verbal-aMCI, only verbal memory impairment; 2) visual-aMCI, only visual memory im..
View full abstractGrants
Awarded by National Research Foundation of Korea
Funding Acknowledgements
This study was supported by a grant from the Korea Healthcare Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare of the Republic of Korea (grant No: HI14C1135), and by the Brain Research Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) (No. 2018M3C7A1056889).