Journal article
Early-phase [18F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury
L Beyer, A Nitschmann, H Barthel, T van Eimeren, M Unterrainer, J Sauerbeck, K Marek, M Song, C Palleis, G Respondek, J Hammes, MT Barbe, Ö Onur, F Jessen, D Saur, ML Schroeter, JJ Rumpf, M Rullmann, A Schildan, M Patt Show all
European Journal of Nuclear Medicine and Molecular Imaging | SPRINGER | Published : 2020
Open access
Abstract
Purpose: Second-generation tau radiotracers for use with positron emission tomography (PET) have been developed for visualization of tau deposits in vivo. For several β-amyloid and first-generation tau-PET radiotracers, it has been shown that early-phase images can be used as a surrogate of neuronal injury. Therefore, we investigated the performance of early acquisitions of the novel tau-PET radiotracer [18F]PI-2620 as a potential substitute for [18F]fluorodeoxyglucose ([18F]FDG). Methods: Twenty-six subjects were referred with suspected tauopathies or overlapping parkinsonian syndromes (Alzheimer’s disease, progressive supranuclear palsy, corticobasal syndrome, multi-system atrophy, Parkins..
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Awarded by Medtronic
Funding Acknowledgements
Open Access funding provided by Projekt DEAL. C.P. received research funding from Luneburg heritage. M.T.B. received research funding from the Felgenhauer-Stiftung, Forschungspool Klinische Studien (University of Cologne), H2020, Medtronic and Boston Scientific. G. U. H was funded by the Deutsche Forschungsgemeinschaft (DFG) under Germany's Excellence Strategy within the framework of the Munich Cluster for Systems Neurology (EXC 2145 SyNergy-ID 390857198), the German Federal Ministry of Education and Research (BMBF, 01EK1605A HitTau), the NOMIS foundation (FTLD project). and received research support from GE Healthcare and Neuropore.