Age-dependent Disturbances of Neuronal and Glial Protein Expression Profiles in Areas of Secondary Neurodegeneration Post-stroke
Murielle G Kluge, Kimberley Jones, Lin Kooi Ong, Emma K Gowing, Michael Nilsson, Andrew N Clarkson, Frederick R Walker
Neuroscience | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2018
Despite the fact that approximately 80% of strokes occur in those aged over 60 years, many pre-clinical stroke studies have been conducted in younger adult rodents, raising debate about translation and generalizability of these results. We were interested in potential age differences in stroke-induced secondary neurodegeneration (SND). SND involves the death of neurons in areas remote from, but connected to, the site of infarction, as well as glial disturbances. Here we investigated potential differences in key parameters of SND in the thalamus, a major site of post-stroke SND. Protein expression profiles in young adult (2-4 months) and aged (22-23 months) mice were analyzed 28 days after a ..View full abstract
The authors disclosed receipt of the following financial support for the research, authorship and/or publication of this article. This study was supported by the National Health and Medical Research Council (NHMRC) of Australia, Hunter Medical Research Institute, Faculty of Health and Medicine Pilot Grant and by the New Zealand Neurological Foundation, Royal Society of New Zealand Project Grant and Brain Research New Zealand CoRE funding (ANC). F.R.W. and M.N. also acknowledge ongoing support from NHMRC Centre for Research Excellence in Stroke Recovery and Rehabilitation.