Chronic stress exacerbates neuronal loss associated with secondary neurodegeneration and suppresses microglial-like cells following focal motor cortex ischemia in the mouse
Kimberley A Jones, Ihssane Zouikr, Madeleine Patience, Andrew N Clarkson, Jorgen Isgaard, Sarah J Johnson, Neil Spratt, Michael Nilsson, Frederick R Walker
Brain, Behavior, and Immunity | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2015
Post-stroke patients describe suffering from persistent and unremitting levels of distress. Using an experimental model of focal cortical ischemia in adult male C57BL/6 mice, we examined whether exposure to chronic stress could modify the development of secondary thalamic neurodegeneration (STND), which is commonly reported to be associated with impaired functional recovery. We were particularly focused on the modulatory role of microglia-like cells, as several clinical studies have linked microglial activation to the development of STND. One month following the induction of cortical ischemia we identified that numbers of microglial-like cells, as well as putative markers of microglial struc..View full abstract
FRW acknowledges project grant support from the Australian National Health and Medical Research Council. MN acknowledges the support from the University of Newcastle's Brawn Fellowship, the Hunter Medical Research Institute (HMRI) and the Sten A. Olsson Foundation for Science and Culture.