Peripheral immune cells infiltrate into sites of secondary neurodegeneration after ischemic stroke
KA Jones, S Maltby, MW Plank, M Kluge, M Nilsson, PS Foster, FR Walker
Brain, Behavior, and Immunity | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2018
Experimental stroke leads to microglia activation and progressive neuronal loss at sites of secondary neurodegeneration (SND). These lesions are remote from, but synaptically connected to, primary infarction sites. Previous studies have demonstrated that immune cells are present in sites of infarction in the first hours and days after stroke, and are associated with increased neurodegeneration in peri-infarct regions. However, it is not known whether immune cells are also present in more distal sites where SND occurs. Our study aimed to investigate whether immune cells are present in sites of SND and, if so, how these cell populations compare to those in the peri-infarct zone. Cells were iso..View full abstract
FRW, MN acknowledge support by the Hunter Medical Research Institute and The University of Newcastle, Australia. PSF is supported by a National Health and Medicine Research Council project grant.