Journal article

Acute and Chronic Stress-Induced Disturbances of Microglial Plasticity, Phenotype and Function

Frederick Rohan Walker, Michael Nilsson, Kimberley Jones

Current Drug Targets | BENTHAM SCIENCE PUBL LTD | Published : 2013

Abstract

Traditionally, microglia have been considered to act as macrophages of the central nervous system. While this concept still remains true it is also becoming increasingly apparent that microglia are involved in a host of nonimmunological activities, such as monitoring synaptic function and maintaining synaptic integrity. It has also become apparent that microglia are exquisitely sensitive to perturbation by environmental challenges. The aim of the current review is to critically examine the now substantial literature that has developed around the ability of acute, sub-chronic and chronic stressors to alter microglial structure and function. The vast majority of studies have demonstrated that ..

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University of Melbourne Researchers