Stress as necessary component of realistic recovery in animal models of experimental stroke
Frederick R Walker, Kimberley A Jones, Madeleine J Patience, Zidan Zhao, Michael Nilsson
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | SAGE PUBLICATIONS INC | Published : 2014
Over the last decade there has been a considerable effort directed toward reformulating the standard approach taken to preclinically model stroke and stroke recovery. The principal objective of this undertaking has been to improve the success with which preclinical findings can be translated. Although several advancements have already been introduced, one potentially critical feature that appears to have been overlooked is psychological stress. Stroke is well recognized to produce high levels of stress in patients, and ongoing exposure to stress is recognized to deleteriously interfere with recovery. The presence of high levels of stress (distress) in stroke patients is also relevant because..View full abstract
FRW acknowledges project grant support from the Australian National Health and Medical Research Council. MN acknowledges the support from the University of Newcastle's Brawn Fellowship, the Hunter Medical Research Institute (HMRI), and the Stan. A. Olsson Foundation for Science and Culture.