Dynamic structural remodelling of microglia in health and disease: A review of the models, the signals and the mechanisms
F Rohan Walker, Sarah B Beynon, Kimberley A Jones, Zidan Zhao, Ratchanipom Kongsui, Murray Cairns, Michael Nilsson
Brain, Behavior, and Immunity | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2014
Microglia are unique cells within the central nervous system because of their biophysical independence. As a result of this unusual property the cells must undergo significant structural remodelling in order to engage and connect with other elements within the central nervous system. Efficient remodelling is required for all activities that microglia are involved in ranging from monitoring synaptic information flow through to phagocytosis of tissue debris. Despite the fact that morphological remodelling is a pre-requisite to all microglial activities, relatively little research has been undertaken on the topic. This review examines what is known about how microglia transform themselves durin..View full abstract
FRW: acknowledges funding support of the National Health and Medical Research Council of Australia and The Hunter Medical Research Institute. MN: acknowledges the support from the University of Newcastle's Brawn Fellowship, the Hunter Medical Research Institute (HMRI) and the Stan.A.Olsson Foundation For Science and Culture.