Journal article

Incidental mucocutaneous cytomegalovirus detection and its predictive value for systemic disease

Carly M Hughes, Stephanie Spring, Ravindi Radalage, Maryza Graham, Claire Dendle, Benjamin A Rogers

Pathology | ELSEVIER | Published : 2020

Abstract

Multiplex polymerase chain reaction (PCR) testing has revolutionised microbiological practice but also increased the number of positive results of uncertain significance. This phenomenon has been seen in the increasing detection of cytomegalovirus (CMV) in mucocutaneous swabs for herpesviruses, the microbiological significance of which is a priori unclear. The aim of our study was to determine if an incidental finding of a positive CMV result represented CMV disease, if it facilitated a timely diagnosis of CMV disease or whether there were any deleterious outcomes. We performed a retrospective review of patients with an incidentally positive PCR result for CMV on external and mucosal swabs, ..

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University of Melbourne Researchers