Journal article

Critical slowing down as a biomarker for seizure susceptibility.

Matias I Maturana, Christian Meisel, Katrina Dell, Philippa J Karoly, Wendyl D'Souza, David B Grayden, Anthony N Burkitt, Premysl Jiruska, Jan Kudlacek, Jaroslav Hlinka, Mark J Cook, Levin Kuhlmann, Dean R Freestone

Nature Communications | Nature Research (part of Springer Nature) | Published : 2020


The human brain has the capacity to rapidly change state, and in epilepsy these state changes can be catastrophic, resulting in loss of consciousness, injury and even death. Theoretical interpretations considering the brain as a dynamical system suggest that prior to a seizure, recorded brain signals may exhibit critical slowing down, a warning signal preceding many critical transitions in dynamical systems. Using long-term intracranial electroencephalography (iEEG) recordings from fourteen patients with focal epilepsy, we monitored key signatures of critical slowing down prior to seizures. The metrics used to detect critical slowing down fluctuated over temporally long scales (hours to days..

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Awarded by National Health and Medical Research Council

Awarded by Ministry of Health of the Czech Republic

Funding Acknowledgements

IEEGPORTAL and National Health and Medical Research Council Project Grant 1130468. C.M. acknowledges support from a NARSAD Young Investigator grant. M.I.M. acknowledges support from the Melbourne Neuroscience Institute Fellowship award. D.R.F., L.K., and M.J.C. acknowledge the support from the Epilepsy Foundation of America, My Seizure Gauge Challenge Funding. P.J. and J.H. acknowledges support from the Ministry of Health of the Czech Republic 17-28427A.