Journal article
A multivariate genome-wide association analysis of 10 LDL subfractions, and their response to statin treatment, in 1868 Caucasians
H Shim, DI Chasman, JD Smith, S Mora, PM Ridker, DA Nickerson, RM Krauss, M Stephens
Plos One | Published : 2015
Open access
Abstract
We conducted a genome-wide association analysis of 7 subfractions of low density lipoproteins (LDLs) and 3 subfractions of intermediate density lipoproteins (IDLs) measured by gradient gel electrophoresis, and their response to statin treatment, in 1868 individuals of European ancestry from the Pharmacogenomics and Risk of Cardiovascular Disease study. Our analyses identified four previously-implicated loci (SORT1, APOE, LPA, and CETP) as containing variants that are very strongly associated with lipoprotein subfractions (log 10Bayes Factor > 15). Subsequent conditional analyses suggest that three of these (APOE, LPA and CETP) likely harbor multiple independently associated SNPs. Further, wh..
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Awarded by National Heart, Lung, and Blood Institute
Funding Acknowledgements
This work was supported by National Institutes of Health grant U19HL069757 to RMK and MS. The replication data from JUPITER was supported by National Heart, Lung, and Blood Institute grant HL117861 to SM. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.