Journal article
Renal tissue PO2 sensing during acute hemodilution is dependent on the diluent
JR Abrahamson, A Read, K Chin, N Mistry, H Joo, JF Desjardins, E Liu, K Thai, DF Wilson, SA Vinogradov, JT Maynes, RE Gilbert, KA Connelly, AJ Baker, C David Mazer, GMT Hare
American Journal of Physiology Regulatory Integrative and Comparative Physiology | AMER PHYSIOLOGICAL SOC | Published : 2020
Abstract
Sensing changes in blood oxygen content (CaO2) is an important physiological role of the kidney; however, the mechanism(s) by which the kidneys sense and respond to changes in CaO2 are incompletely understood. Accurate measurements of kidney tissue oxygen tension (PktO2) may increase our understanding of renal oxygen-sensing mechanisms and could inform decisions regarding the optimal fluid for intravascular volume resuscitation to maintain renal perfusion. In some clinical settings, starch solution may be nephrotoxic, possibly due to inadequacy of tissue oxygen delivery. We hypothesized that hemodilution with starch colloid solutions would reduce PktO2 to a more severe degree than other dilu..
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Funding Acknowledgements
Support for this study was provided by the Innovation Fund (SMH-17-014), St. Michael's Hospital (to G. M. Hare), University of Toronto Merit Awards (to C. D. Mazer, A. J. Baker, J. T. Maynes, and G. M. Hare). R. E. Gilbert is the Canada Research Chair in Diabetes Complication and support for this work was provided by the Canada Research Chair's Program.