Journal article

The neuroregenerative effects of topical decorin on the injured mouse cornea

Mengliang Wu, Laura E Downie, Liam M Grover, Richard JA Moakes, Saaeha Rauz, Ann Logan, Haihan Jiao, Lisa J Hill, Holly R Chinnery



BACKGROUND: The cornea is innervated with a rich supply of sensory nerves that play important roles in ocular surface health. Any injury or pathology of the corneal nerves increases the risk of dry eye disease and infection. This study aims to evaluate the therapeutic potential of topical decorin to improve corneal nerve regeneration in a mouse model of sterile epithelial abrasion injury. METHODS: Bilateral central corneal epithelial abrasions (2-mm, Alger Brush) were performed on young C57BL/6 J mice to remove the corneal sensory nerves. Decorin, or vehicle, was applied topically, three times per day for 1 week or every 2 h for 6 h. Spectral-domain optical coherence tomography was performed..

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Awarded by National Health and Medical Research Council Project Grant (Australia)

Awarded by Medical Research Council (UK)

Funding Acknowledgements

This research was supported by the National Health and Medical Research Council Project Grant (Australia) (HRC APP1126540). This work was also supported by the Medical Research Council (UK) (MR/N019016/1) and the Healthcare Technologies Research Institute and the NIHR Trauma Management MedTech Cooperative (MIC). MW is supported by an Australian Government Research Training Program Scholarship.