Journal article

Dementia in long-term Parkinson's disease patients: a multicentre retrospective study

Jennifer YY Szeto, Courtney C Walton, Alexandra Rizos, Pablo Martinez-Martin, Glenda M Halliday, Sharon L Naismith, K Ray Chaudhuri, Simon JG Lewis

NPJ PARKINSONS DISEASE | NATURE PUBLISHING GROUP | Published : 2020

Abstract

While several studies have investigated the clinical progression of cognitive decline in Parkinson's disease (PD) patients, there has been a paucity of data on specifically evaluating PD patients with a disease duration of over 20 years. This study retrospectively investigated the frequency of dementia in PD (PDD) patients with a disease duration of over 20 years assessed in research clinics across the UK and Australia. Data from 2327 PD patients meeting the United Kingdom Parkinson's Disease Society Brain Bank Criteria was pooled. A diagnosis of probable PDD was made according to the Movement Disorder Society Level 1 criteria. Thirty-six participants had a disease duration of at least 20 ye..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by NHMRC Senior Principal Research Fellowship


Funding Acknowledgements

We acknowledge data collection efforts by all contributors, collaborators, and administrative staff of the NILS study and the ForeFront research studies. This paper presents independent research funded by the National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre and Dementia Unit at South London and Maudsley NHS Foundation Trust and King's College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health. ForeFront is a large collaborative research group dedicated to the study of neurodegenerative diseases and is funded by the National Health and Medical Research Council of Australia (NHMRC) Grants (#1037746, #1095127, and #1060992), as well as the Sydney Research Excellence Initiative 2020. G.H. is supported by a NHMRC Senior Principal Research Fellowship (#1079679). A.R. is supported by NIHR (UK) Clinical Research Network (CRN core funding at Kings College Hospital)