Journal article
Liver Fibrosis Indices and Outcomes After Primary Intracerebral Hemorrhage
NS Parikh, H Kamel, BB Navi, C Iadecola, AE Merkler, A Jesudian, J Dawson, GJ Falcone, KN Sheth, DJ Roh, MSV Elkind, DF Hanley, WC Ziai, SB Murthy
Stroke | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020
Abstract
Background and Purpose - Cirrhosis - clinically overt, advanced liver disease - is associated with an increased risk of hemorrhagic stroke and poor stroke outcomes. We sought to investigate whether subclinical liver disease, specifically liver fibrosis, is associated with clinical and radiological outcomes in patients with primary intracerebral hemorrhage. Methods - We performed a retrospective cohort study using data from the Virtual International Stroke Trials Archive-Intracerebral Hemorrhage. We included adult patients with primary intracerebral hemorrhage presenting within 6 hours of symptom onset. We calculated 3 validated fibrosis indices - Aspartate Aminotransferase-Platelet Ratio Ind..
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Awarded by National Institute of Neurological Disorders and Stroke
Funding Acknowledgements
Dr Parikh was supported by National Institutes of Health (NIH; T32NS07153, Principal Investigator: Dr Elkind). Dr Kamel is supported by NIH (R01NS097443, U01NS095869) and Michael Goldberg Research Fund. Dr Navi is supported by NIH (K23NS091395), Florence Gould Endowment for Discovery in Stroke. Dr Iadecola is supported by NIH (R01NS34179, R37-NS089323, R01-NS100447, 1R01-NS095441, R01-NS/HL37853). Dr Merkler is supported by American Heart Association (AHA; 18CDA34110419), Leon Levy Foundation. Dr Jesudian is supported by Society of Interventional Radiology Foundation. Dr Falcone is funded by NIH (K76AG059992), AHA (18IDDG34280056), Yale Pepper Scholar Award (P30AG021342), Neurocritical Care Society Research Fellowship. Dr Sheth is supported by NIH (U01NS106513, U24NS107215, U24NS107136, R01NR018335), AHA (17CSA33550004). Dr Elkind is supported by NIH (R01NS029993, U01NS095869). Dr Hanley is supported by NIH (1U01NS080824, U24TR001609). Dr Ziai is supported by NIH (1U01NS080824). Dr Murthy is supported by NIH (K23NS105948), Leon Levy Foundation.